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Creators/Authors contains: "Kim, Tae Hyun"

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  1. ; ; ; ; ; ; ; ; ; ; et al (, Science Advances)
    A flexible biomimetic polymer with high thermal response is created for temperature mapping and long-wave IR sensing. 
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  2. ; ; (, Genome Biology)
    Abstract Many existing pipelines for scRNA-seq data apply pre-processing steps such as normalization or imputation to account for excessive zeros or “drop-outs. Here, we extensively analyze diverse UMI data sets to show that clustering should be the foremost step of the workflow. We observe that most drop-outs disappear once cell-type heterogeneity is resolved, while imputing or normalizing heterogeneous data can introduce unwanted noise. We propose a novel framework HIPPO (Heterogeneity-Inspired Pre-Processing tOol) that leverages zero proportions to explain cellular heterogeneity and integrates feature selection with iterative clustering. HIPPO leads to downstream analysis with greater flexibility and interpretability compared to alternatives. 
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